Adult & childn ≥40 kg Mild to moderate infection 500 mg every 12 hr or 250 mg every 8 hr.
Severe infection May increase dose up to 875 mg every 12 hr or 500 mg every 8 hr.
Lower resp tract infection 875 mg every 12 hr or 500 mg every 8 hr.
Community-acquired pneumonia Combination w/ macrolide or doxycycline: 1 g tid. Max duration: 5 days.
Simple acute UTI Two 3 g doses w/ 10-12 hr intervals.
Gonorrhea 3 g as single dose.
H. pylori GIT infection Combination w/ PPI & clarithromycin or metronidazole (triple therapy) or PPI, clarithromycin & metronidazole (quadruple therapy): 1 g bid for 14 days.
Prophylaxis of bacterial endocarditis 2 g 30-60 min before procedure.
Childn <40 kg Mild to moderate infection 125 mg every 8 hr.
Severe infection May increase dose up to 250 mg every 8 hr.
Acute otitis media 750 mg bid for 2 days may be used as alternative course of treatment.
Prophylaxis of bacterial endocarditis 50 mg/kg 30-60 min before procedure.
Renal impairment w/ GFR 10-30 mL/min 250-500 mg every 12 hr,
<10 mL/min 250-500 mg every 24 hr.
Hemodialysis 250-500 mg every 24 hr after dialysis.
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